Endocrine Abstracts

The limitations of s.c. insulin lead to post prandial hyperglycaemia and a high risk of hypoglycaemia particularly in the post-absorptive state. Nocturnal hypoglycaemia continues to be a common and major problem for patients with insulin treated diabetes and is a major barrier in preventing patients reaching tight glycaemic targets.The development of basal insulin analogues, insulin glargine and insulin detemir which deliver insulin over a longer period ...

Bone turnover decreases markedly following both oral glucose and feeding. The mechanism for this is unclear. The aim of this study was to examine whether insulin itself could be responsible for the effect of feeding. We examined the acute effect of a hyperinsulinemic euglycemic clamp (E) and stepwise hyperinsulinemic hypoglycemic clamp (H) on bone turnover and PTH. Sixteen healthy male volunteers (mean age 22) attended on two occasions at 0800 after an overnight fast. The stud...